How Cells Thwart Cancer

By Katherine Bourzac

Description text

This elaborate diagram shows the complex network of reactions that yeast cells have to DNA damage. It reveals interactions between genes (rectangles) and proteins (diamonds and circles), with interacting molecules linked by arrows. Genes that became more active when the cell was exposed to a toxin are in yellow; less active ones in blue. The diagram implicates many genes not involved in DNA repair itself, from lipid metabolism genes to stress response genes. It could give researchers new ideas for therapeutic targets for cancer.