Ultrasensitive Test for Heart Attacks, Alzheimer's

By Kevin Bullis

Description text

Nanosphere uses what it calls "bio-barcodes" for protein detection. Gold nanoparticles are decorated with an antibody that will bind to a target protein. Also attached to the particle are hundreds of strands of DNA with identical sequences -- these will serve eventually as the "barcodes."  Magnetic beads, also with antibodies, attach to the protein as well. A magnetic field then attracts the bundle, making it possible to isolate it from the rest of a sample. Once isolated, the DNA barcodes are released, hundreds for each protein captured. These DNA strands are then detected using the method described in the previous slide.