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Now Available: Innovators Under 35 2013 See The 2013 List »

Balaji Narasimhan, 32

Devises time-release polymers to replace multiple vaccine injections

Iowa State University

CHEMICAL ENGINEER Balaji Narasimhan is determined to help prevent common world-wide diseases such as tetanus and diphtheria. These illnesses currently require four to five injections to build up a subject’s immunity, a fact that is particularly troublesome in populations with limited access to health care. Narasimhan, an associate professor at Iowa State University, is trying to achieve the same effects with a single dose, by encapsulating vaccines in specially tailored biodegradable polymers. When injected, the polymers slowly release the vaccines in precise amounts at precise times over a one-year period, thereby maximizing immune response and making booster shots unnecessary. The precision that Narasimhan has achieved in lab tests is better than that for previous drug encapsulation systems. Narasimhan is also devising noninteractive polymers to deliver fragile proteins involved in cancer therapies. One advantage is that his polymers resist water, and thus degradation, better than other drug delivery materials. Narasimhan expects both systems to be ready for human testing within five years. Before his work with polymer-based drug delivery,Narasimhan and researchers from the Swiss chemical company Clariant invented a more efficient process for making photoresists—polymers used in the manufacture of computer chips. Clariant is now operating a pilot photoresist production facility in New Jersey that uses this process.

2003 TR35 Winners

Scott Backhaus

Invented a novel, high-efficiency engine powered by sound waves

Zhenan Bao

Fabricates organic semiconductors used in flexible and cheap electronic devices

Marcela Bilek

Designs coatings to improve implanted medical devices and industrial tools

Daniel Bond

Turns sea muck into fuel cell power plants

Michael Bowman

Builds microturbines that could become the power plant of choice in many settings

Colin Bulthaup

Developed new fabrication methods that could slash the cost of chip manufacturing

Karen Burg

Engineered a minimally invasive process to rebuild tissue for breast cancer survivors

Xiangfeng Duan

Transforms nanowires into incredibly small transistors for powerful, flexible computers

Stephen Empedocles

Formulates business strategy for one of nanotechs leading startups

Vladislav Gavrilets

Designs flight control technology that could lead to unmanned autonomous helicopters

Scott Gaynor

Devises processes used to make polymers with improved properties

Cary Gunn

Shrinks optical circuitry to speed transmissions on phone and Internet networks

Yu Huang

Fashions three-dimensional grids of nanowires that act as electronic circuits

Jordan Katrine

Makes higher-density hard drives using magnetic nanomaterials

Krishna Kumar

Improves the stability and effectiveness of protein-based drugs

David M. Lynn

Synthesizes polymers that are better able to deliver therapeutic genes

David A. Muller

Images the individual atom that are critical to a transistors electronic properties

Yasunobu Nakamura

Achieved a breakthrough that could help make quantum computing a reality

Balaji Narasimhan

Devises time-release polymers to replace multiple vaccine injections

Ravikanth Pappu

Fights credit card forgery with glass-bead “keys”

Ainissa G. Ramirez

Formulated an advanced universal solder for electronics and optics

Christian Rehtanz

Adds smarts to high-voltage power lines so they can deliver more electricity

Manfred Stefener

Constructs small fuel cells to efficiently power laptop computers

Claire Tomlin

Writes software that could alleviate air congestion and lead to far fewer delays at airports

Stephen Turner

Built a tiny device that greatly speeds up DNA sequencing

S. Travis Waller

Writes algorithms that determine why traffic jams form and how to ease them

Ralf Wehrspohn

Fabricates nanotube crystals that can route optical telecommunications signals faster than competing chips

Peidong Yang

Assembles nanowires that could revolutionize lasers and computers


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