Melissa Mahoney, 32
Making materials to treat brain damage
University of Colorado at Boulder
Nerve cell transplants offer tremendous promise for patients who are suffering the effects of stroke, or from Parkinsons disease or other neurodegenerative illnesses. But experiments in rodents showed that about 95 percent of cells transplanted into the brain die before they can help the recipient. Melissa Mahoney is working to develop hydrogel materials that can house the cells, protecting them and supplying them with proteins that encourage their growth. In collaboration with scientists at the University of Colorado at Denvers Health Sciences Center, Mahoney, an assistant professor of chemical engineering, plans to test these cell-loaded gels in rats within the next year.
2005 TR35 Winners
Thijn Brummelkamp
Silencing the genes that cause cancer
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Discovering how genes are regulated
Matthew DeLisa
Delivering more medicine from microbes
Kevin Eggan
Using cloning to study degenerative diseases
Paul Hergenrother
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Trey Ideker
Defining and advancing systems biology
Hang Lu
Designing microfluidic chips to study cells
Melissa Mahoney
Making materials to treat brain damage
Daniel Riskin
Developing devices for wound closure and early heart-attack intervention.
Shiladitya Sengupta
Delivering drugs to cancer cells

