Shana Kelley, 34
Builds nanoscale electrochemical and electrical sensors to detect medically relevant gene sequences and proteins.
Assistant professor, Boston College
Cofounded San Diego, CAs GeneOhm Sciences to produce molecular diagnostics based on one such technology.
2004 TR35 Winners
Vadim Backman
Found a way to spot colon cancer earlier than was previously possible
Yaakov Benenson
He wants to replace physicians with molecular machines that diagnose and treat diseases with phenomenal precision.
Rebekah Drezek
Develops photonic technologies that use targeted nanomaterials to detect, monitor, and treat breast and gynecologic cancers painlessly, and at a fraction of the cost of conventional approaches.
Ryan Egeland
Slashed the cost of producing a DNA chip from hundreds of dollars to a few dollars by combining microfluidics, computer control, and novel electrochemistry.
Michael Elowitz
Combines existing genes to build artificial biological pathways, or "circuits," that operate inside cells.
Tim Gardner
Constructs computer models of cellular pathways in order to optimize bacteria for energy production and environmental remediation.
Colin Hill
Aims to more than double human trials success rate by virtually prescreening drugs in computer models of human cells.
Shana Kelley
Builds nanoscale electrochemical and electrical sensors to detect medically relevant gene sequences and proteins.
Gloria Kolb
Devised a way to remove kidney stones more cost effectively and less invasively by taking advantage of the ureters tendency to dilate around foreign objects.
Jörg Lahann
Designed an electrically switchable surface coating that can alternate between attracting and repelling water.
Eric C. Leuthardt
Showed that a patient could achieve real-time control of a computer via electrodes placed on the brains surface.
David Liu
Applies evolutionary principles to synthetic molecules by linking starting materials to DNA strands.
Frank Lyko
Aims to reprogram cancer cells to be more like normal cells by developing compounds that block the aberrant modification of DNA in cancer cells.
Lauren Meyers
Helped public-health officials control epidemics of walking pneumonia and SARS with sophisticated mathematical models that predict how a disease will spread through networks of human interactions.
Ananth Natarajan
Bridging the gap between research and patient care.
Vasilis Ntziachristos
Facilitated noninvasive optical imaging of proteins and other molecules in the body, which could lead to ultraprecise diagnosis of cancer and other diseases.
Shayn Peirce
Models how individual cells in tissues migrate, multiply, and develop during processes such as blood vessel growth. The models should aid tissue engineering and drug development.
Cristoph Schaffrath
Discovered an enzyme that could enable environmentally benign production of fluorine-containing compounds such as Teflon and Prozac, which are now made via noxious chemical processes.
Monisha Scott
Determined how small, natural proteins boost the immune response.
Vikram Sheel Kumar
Developed interactive software that motivates patients to manage chronic diseases such as diabetes and AIDS.
Christina Smolke
Fine-tunes the activity of individual genes via an adaptable technology
Kahp-Yang Suh
Came up with the first method that allows researchers to pattern proteins and cells directly onto glass or plastic surfaces or within microfluidic channels without complicated preparation.
Olga Troyanskaya
Devised sophisticated and accurate computer algorithms for analyzing data generated using DNA microarrays.
Smruti Vidwans
Development of drugs to assist in the battle against TB.
Lei Wang
Expanded the genetic code in order to allow living cells to incorporate new, unnatural building blocks into the proteins that they make.
Sandra Waugh Ruggles
Uses clever testing schemes to determine which protein- slicing enzymes make the cut as potential drugs.
Xiaowei Zhuang
She has filmed a single influenza virus infecting a cell.
