Derek Hansford, 29
Materials
Ohio State University
Derek Hansford’s unobtrusive bearing is just what you’d expect from someone who designs ways to sneak drugs past the immune system. Hansford has been fabricating tiny polymer particles that can hold drugs and be injected into a patient’s bloodstream. Once there, they could hunt down tumors and release their drugs, without affecting healthy cells. Along the way, the particles would shield the drugs from degrading enzymes and would not elicit attacks from the immune system—a common problem for cancer drugs—because they do not attract immune cells. Although other bioengineers are making polymer drug-delivery devices, none has made large numbers of uniform particles small enough to travel in the blood-stream; each of Hansford’s particles is about the size of a red blood cell. The scientist has adapted a technique called soft lithography to make the particles, casting hundreds of millions of them in varied shapes out of reusable molds. Startup company iMedd plans to license his technology. Hansford will now try to make particles for inhalable drugs—an alternative to injections.
2002 TR35 Winners
Ewan Birney
Biotechnology
Stephen Boppart
Medicine
Fiona Brinkman
Biotechnology
Stephen Brossette
Medicine
Chris Burge
Biotechnology
Benjamin Cravatt
Biotechnology
Nathaniel David
Biotechnology
Jennifer Elisseeff
Medicine
Susan Hagness
Medicine
Derek Hansford
Materials
John Harrington
Medicine
Suzie Hwang Pun
Medicine
J. Joseph Kim
Medicine
Steven Laken
Medicine
Corinna E. Lathan
Medicine
Kelvin Lee
Medicine
Surya Mallapragada
Medicine
Sean J. Morrison
Medicine
Milan Mrksich
Materials
Stephen OConnor
Biotechnology
Alexander Olek
Biotechnology
Vijay Pande
Biotechnology
Stephen Quake
Materials
David Sabatini
Biotechnology
John Santini
Medicine
David Schaffer
Medicine
Kevin Shakesheff
Materials
Vivek Subramanian
Materials
Christoph Westphal
Biotechnology

