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Now Available: Innovators Under 35 2013 See The 2013 List »

Kevin Shakesheff, 32

Materials

University of Nottingham

The human immune system defends against foreign objects with vigilance, but Kevin Shakesheff wants to create lasting peace between synthetic surfaces and the biological world. He is building polymer scaffolds, on which living cells can grow, to form the backbones of what will one day be transplant-ready organs, as well as drug delivery vehicles that can steer themselves to target sites. That work began when the pharmaceutical sciences graduate spent a year in the lab of MIT bioengineering pioneer Robert Langer. He returned to the University of Nottingham in his native England to start his own lab. There, Shakesheff figured out how to incorporate stem cells as well as support cells that he calls the “unsung heroes” of tissue regeneration into biodegradable polymer structures for organs. Shakesheff is now using the technique to develop small polymer capsules that can deliver human cells to injury sites. Last year, the hard-working Shakesheff founded Regentec in Nottingham to commercialize his work. He’s forging agreements with pharmaceutical companies to mass- produce miniature tissue and organ samples for drug testing.

2002 TR35 Winners

Ewan Birney

Biotechnology

Fiona Brinkman

Biotechnology

Chris Burge

Biotechnology

Benjamin Cravatt

Biotechnology

Nathaniel David

Biotechnology

Susan Hagness

Medicine

Derek Hansford

Materials

J. Joseph Kim

Medicine

Steven Laken

Medicine

Kelvin Lee

Medicine

Milan Mrksich

Materials

Stephen OConnor

Biotechnology

Alexander Olek

Biotechnology

Vijay Pande

Biotechnology

Stephen Quake

Materials

David Sabatini

Biotechnology

John Santini

Medicine

David Schaffer

Medicine

Christoph Westphal

Biotechnology

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