Select your localized edition:

Close ×

More Ways to Connect

Discover one of our 28 local entrepreneurial communities »

Be the first to know as we launch in new countries and markets around the globe.

Interested in bringing MIT Technology Review to your local market?

MIT Technology ReviewMIT Technology Review - logo


Now Available: Innovators Under 35 2013 See The 2013 List »

Ellis Meng, 34

Micropumps deliver drugs that prevent blindness

University of Southern California

Treating many of the diseases that cause blindness involves frequent, painful injections directly into the eyes, putting patients at risk for infection, cataracts, and torn retinas. Ellis Meng, an assistant professor of biomedical and electrical engineering, has built an implantable pump to deliver medications more safely.

About the size of a watch battery, her device uses a microfluidic pump to push medications from a reservoir through a small tube and into the eye. A surgeon implants the pump and reservoir on the outer surface of the eye; only the tube enters the eye itself. And unlike existing implants that must be replaced periodically as they run out of drugs, Meng's is refillable. Instead of weekly injections or monthly surgeries, a patient could take just one trip to the operating room, dramatically reducing both pain and risk. Meng is still testing the eye pump in animals but hopes it can be tested in humans within five years. --Jocelyn Rice

Prescription pump: Ellis Meng's implantable device for delivering drugs to the eye consists of a chamber that stores the medication; a pump; and a tiny tube that enters the eye. Within the pump, wirelessly powered platinum electrodes produce a current that splits water into hydrogen and oxygen gas, inflating a miniature bellows to force medication out of the reservoir, through the tube, and into the eye.

1. Implantable drug pump

2. Delivery tube

3. Refill port

4. Drug reservoir

5. Polymer bellows

6. Pump base and electrodes

Credit: Bryan Christie Design

2009 TR35 Winners

Jorge Conde (video)

Offering consumers whole-genome sequencing--and software to interpret it

José Gómez-Márquez (video)

Practical medical devices for use in poor countries

Michelle Khine (video)

A children’s toy inspires a cheap, easy production method for high-tech diagnostic chips

Erez Lieberman-Aiden

Quantitative tools offer new insights into evolution

Andrew Lynn

Repairing joints by stimulating regrowth in bone and cartilage

Ellis Meng

Micropumps deliver drugs that prevent blindness

C. Shad Thaxton

Nanoparticles could treat cardiovascular disease by mimicking “good cholesterol”


More Innovators Under 35: