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Now Available: Innovators Under 35 2013 See The 2013 List »

Martha Bulyk, 33

Discovering how genes are regulated

Harvard Medical School

Figuring out how genes coordinate the complex phenomena of life involves more than deciphering a DNA sequence. Proteins called transcription factors control genes by attaching to DNA; discovering where each of these proteins binds is critical to understanding how genes regulate working cells. Martha Bulyk has taken the gene chip technology originally developed to measure gene activity and adapted it to determine the DNA binding preferences of proteins. The technology replaces painstaking assays with efficient screens, which could aid research on diseases that are affected by mutations in transcription factors or in their binding sites, such as hypertension, cancer, and diabetes.

2005 TR35 Winners

Thijn Brummelkamp

Silencing the genes that cause cancer

Martha Bulyk

Discovering how genes are regulated

Matthew DeLisa

Delivering more medicine from microbes

Kevin Eggan

Using cloning to study degenerative diseases

Paul Hergenrother

Discovering drugs that defy convention

Trey Ideker

Defining and advancing systems biology

Hang Lu

Designing microfluidic chips to study cells

Melissa Mahoney

Making materials to treat brain damage

Daniel Riskin

Developing devices for wound closure and early heart-attack intervention.

Shiladitya Sengupta

Delivering drugs to cancer cells

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