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Now Available: Innovators Under 35 2013 See The 2013 List »

Kevin Eggan, 31

Using cloning to study degenerative diseases

Harvard University

While earning his PhD, Kevin Eggan helped make Rudolf Jaenischs lab at the Whitehead Institute for Biomedical Research a preeminent cloning lab. Eggan became "arguably the most skillful mouse cloner in this country," says Jaenisch. Eggan used those skills to clone mice from neurons, proving that animals could be cloned from even the most specialized cells in the body -- a feat that many scientists considered impossible. Eggan also helped explain how cloning "reprograms" the genetic material from an adult mouse cell, identifying the changes that take place to reset the nucleus to the beginning of development.

Eggan, now an assistant professor of molecular and cellular biology, plans to create human stem cell lines from patients with neurodegenerative disorders such as Parkinsons and Lou Gehrigs diseases, in order to study disease development and search for new drugs. He has also begun studying nuclear reprogramming in human cells in the hope of finding a way to create patient-specific embryonic stem cells without using human eggs.

2005 TR35 Winners

Thijn Brummelkamp

Silencing the genes that cause cancer

Martha Bulyk

Discovering how genes are regulated

Matthew DeLisa

Delivering more medicine from microbes

Kevin Eggan

Using cloning to study degenerative diseases

Paul Hergenrother

Discovering drugs that defy convention

Trey Ideker

Defining and advancing systems biology

Hang Lu

Designing microfluidic chips to study cells

Melissa Mahoney

Making materials to treat brain damage

Daniel Riskin

Developing devices for wound closure and early heart-attack intervention.

Shiladitya Sengupta

Delivering drugs to cancer cells

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